We are a leader in advancing the new in vitro metabolism technology for bioaccumulation.
KJ Scientific LLC, a certified WOSB (Woman Owned Small Business), is located at the Texas Life Sciences Collaboration Center in Georgetown, Texas. We are the first environmental testing biotech company in the world that focuses on using new technology to analyze chemicals (e.g., pesticides, personal care products, consumer goods, pharmaceuticals, fragrances, cosmetics) for bioaccumulation (i.e. accumulation in living organisms’ tissues). Our work impacts the potential results that may affect human and wildlife health.
KJ Scientific, GmbH was established in Switzerland in 2015 and is currently domiciled in Burgdorf. We have ongoing collaborations with Dr. Helmut Segner at the University of Bern.
KJ Scientific and SC Johnson are in a partnership as one of the 7 laboratories in the world that participated in the OECD Ring Trial (OECD 3.13: New Test Guidelines in vitro Fish Hepatic Metabolism) using trout hepatocytes and liver S9 fractions to test various chemicals for bioaccumulation potential.
Our team has the experience, expertise and knowledge working at many Contract Research Organizations under GLP (Good Lab Practices).
We provide both services (contract studies) and products (fish liver sub-cellular fractions & hepatocytes) and utilize new and exciting alternative technology (trout in vitro metabolism assay) to determine bioaccumulation potential of chemicals.
We utilize the trout in vitro metabolism biochemical assay using fish livers (Fay et al; 2015. In: Current Protocols Toxicology 65:4.42.1-29; Johanning et al., 2012. In: Current Protocols Toxicology 14.10.1-28) to assess metabolism and determine bioaccumulation potential (i.e. BCF or Bioconcentration Factor used by regulators). Results from the in vitro metabolism test are utilized in the in vitro to in vivo extrapolation model to generate the BCF values.
The European Commission through the REACH (Registration, Evaluation, Authorization and Restriction of Chemicals) initiative requires chemicals to be tested for Persistency, Bioaccumulation, and Toxicity (PBT) to ensure a high level of protection to human health and the environment, and to promote alternative methods to assess hazardous substances that will reduce the number of tests on animals. Chemicals with specific characteristics and production over 1 ton per year, are required to undergo testing before going into the market.
The use of this alternative method will reduce the cost of testing chemicals; decrease the number of animals used for testing and diminish the experimentation time significantly.